Publications where we participated:


"Genetic and functional characterization of putative Ras/Raf interaction inhibitors in C. elegans and mammalian cells", Journal of Molecular Signaling 2010, 5:2-14

"Patented inhibitors of p53–Mdm2 interaction (2006 – 2008)", Expert Opin. Ther. Patents 2010, 20(2), 179-191

"Molecular Basis for the Inhibition of p53 by Mdmx" Cell Cycle 2007, 6:19, 2386-2392.

"In vitro and in vivo synergy of MCP compounds with mitogen-activated protein kinase pathway- and microtubule-targeting inhibitors." Mol. Cancer Ther. 2007, 6, 898-906.

"K-Ras Promotes Growth Transformation and Invasion of Immortalized Human Pancreatic Cells by Raf and Phosphatidylinositol 3-Kinase Signaling." Cancer Res. 2007, 67, 2098-2106.

"Development of a Yeast Two-hybrid Screen for Selection of Human Ras-Raf Protein Interaction Inhibitors." in “Chemical Genomics: Reviews and Protocols” E.D. Zanders (ed.), Humana Press, Totowa, New Jersey, 2005.

"Protein-Protein Interactions: A Molecular Cloning Manual", Erica A. Golemis, Peter D. Adams (eds), Cold Spring Harbor Laboratory Press, 2005

"Inhibitors of Ras/Raf-1 interaction identified by two-hybrid screening revert Ras-dependent transformation phenotypes in human cancer cells", PNAS 2002.

Medicinal Chemistry

"Initial Design and Synthesis of Conformationally Restricted and Pharmacophore-Based Scaffold Hopping Analogs of a Ras Pathway Modulator and Evaluation of Their MAPK Inhibitory Activities", Letters in Drug Design & Discovery, 2006, 3, 625-630.

"Chemistry for Chemical Genomics." in "Chemical Genomics: Reviews and Protocols", E.D. Zanders (ed.), Humana Press, Totowa, New Jersey, 2005.

"Solution phase parallel synthesis and evaluation of MAPK inhibitory activities of close structural analogues of a Ras pathway modulator", Bioorg. Med. Chem. Lett. 2004, 14, 3957–3962.

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