Publications where we participated:

Biology

"Re-purposing clinical kinase inhibitors to enhance chemosensitivity by overriding checkpoints.", Cell Cycle 2014, Jun 23;13(14).

"A two-hybrid approach to identify inhibitors of the RAS-RAF interaction.", The Enzymes, Vol. 33, Burlington: Academic Press 2013, pp. 213-248.

"Genetic and functional characterization of putative Ras/Raf interaction inhibitors in C. elegans and mammalian cells.", J. Mol Signal. 2010 Feb 23;5(1):2

"Ras-driven transformation of human nestin-positive pancreatic epithelial cells..", Methods Enzymol. 2008, 439, 451-65.

"Selective Raf inhibition in cancer therapy.", Expert Opin. Ther. Targets 2007, 11(12),1587-1609.

"Context-dependent roles of mutant B-Raf signaling in melanoma and colorectal carcinoma cell growth.", Mol. Cancer Ther. 2007, 6(8):2220-9.

"Molecular Basis for the Inhibition of p53 by Mdmx", Cell Cycle 2007, 6:19, 2386-2392.

"In vitro and in vivo synergy of MCP compounds with mitogen-activated protein kinase pathway- and microtubule-targeting inhibitors." , Mol. Cancer Ther. 2007, 6, 898-906.

"K-Ras Promotes Growth Transformation and Invasion of Immortalized Human Pancreatic Cells by Raf and Phosphatidylinositol 3-Kinase Signaling." , Cancer Res. 2007, 67, 2098-2106.

"Development of a Yeast Two-hybrid Screen for Selection of Human Ras-Raf Protein Interaction Inhibitors." in “Chemical Genomics: Reviews and Protocols” E.D. Zanders (ed.), Humana Press, Totowa, New Jersey, 2005.

"Protein-Protein Interactions: A Molecular Cloning Manual", Erica A. Golemis, Peter D. Adams (eds), Cold Spring Harbor Laboratory Press 2005

"Inhibitors of Ras/Raf-1 interaction identified by two-hybrid screening revert Ras-dependent transformation phenotypes in human cancer cells", PNAS 2002.

Medicinal Chemistry

"Isoquinolin-1-one inhibitors of the MDM2-p53 interaction.", ChemMedChem 2008 3(7), 1118-28.

"Initial Design and Synthesis of Conformationally Restricted and Pharmacophore-Based Scaffold Hopping Analogs of a Ras Pathway Modulator and Evaluation of Their MAPK Inhibitory Activities", Letters in Drug Design & Discovery 2006, 3, 625-630.

"Chemistry for Chemical Genomics." in "Chemical Genomics: Reviews and Protocols", E.D. Zanders (ed.), Humana Press, Totowa, New Jersey, 2005.

"Solution phase parallel synthesis and evaluation of MAPK inhibitory activities of close structural analogues of a Ras pathway modulator.", Bioorg. Med. Chem. Lett. 2004, 14, 3957-3962.

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