Publications

Publications

Biology

  • ``Re-purposing clinical kinase inhibitors to enhance chemosensitivity by overriding checkpoints.``

    Cell Cycle 2014, Jun 23;13(14)

  • ``A two-hybrid approach to identify inhibitors of the RAS-RAF interaction.``

    The Enzymes, Vol. 33, Burlington: Academic Press 2013, pp. 213-248.

  • ``Genetic and functional characterization of putative Ras/Raf interaction inhibitors in C. elegans and mammalian cells.``

    J. Mol Signal. 2010 Feb 23;5(1):2

  • ``Ras-driven transformation of human nestin-positive pancreatic epithelial cells..``,
    Methods Enzymol. 2008, 439, 451-65.
  • ``Selective Raf inhibition in cancer therapy.``
    Expert Opin. Ther. Targets 2007, 11(12),1587-1609.
  • ``Context-dependent roles of mutant B-Raf signaling in melanoma and colorectal carcinoma cell growth.``

    Mol. Cancer Ther. 2007, 6(8):2220-9.

  • ``Molecular Basis for the Inhibition of p53 by Mdmx``
    Cell Cycle 2007, 6:19, 2386-2392.
  • ``In vitro and in vivo synergy of MCP compounds with mitogen-activated protein kinase pathway- and microtubule-targeting inhibitors.``

    Mol. Cancer Ther. 2007, 6, 898-906

  • ``K-Ras Promotes Growth Transformation and Invasion of Immortalized Human Pancreatic Cells by Raf and Phosphatidylinositol 3-Kinase Signaling.``

    Cancer Res. 2007, 67, 2098-2106.

  • ``Development of a Yeast Two-hybrid Screen for Selection of Human Ras-Raf Protein Interaction Inhibitors.``

    in “Chemical Genomics: Reviews and Protocols” E.D. Zanders (ed.), Humana Press, Totowa, New Jersey, 2005.

  • ``Protein-Protein Interactions: A Molecular Cloning Manual``
    Erica A. Golemis, Peter D. Adams (eds), Cold Spring Harbor Laboratory Press 2005
  • ``Inhibitors of Ras/Raf-1 interaction identified by two-hybrid screening revert Ras-dependent transformation phenotypes in human cancer cells``
    PNAS 2002
  • ``A novel HSP90 inhibitor-drug conjugate to SN38 is highly effective in small cell lung cancer (SCLC)``
    Gaponova AV, Nikonova A, Deneka AY, Kopp MC, Kudinov AE, Skobeleva N, Khazak V, Shin Ogawa L, Cai KQ, Duncan KE, Duncan JS, Egleston BL, Proia DA, Boumber Y, Golemis EA. Clin Cancer Res. 2016 Jun 7. pii: clincanres.3068.2015. [Epub ahead of print] PubMed PMID: PMID: 27267850

Medicinal Chemistry

  • ``Isoquinolin-1-one inhibitors of the MDM2-p53 interaction.``

    ChemMedChem 2008 3(7), 1118-28

  • ``Initial Design and Synthesis of Conformationally Restricted and Pharmacophore-Based Scaffold Hopping Analogs of a Ras Pathway Modulator and Evaluation of Their MAPK Inhibitory Activities``

    Letters in Drug Design & Discovery 2006, 3, 625-630

  • ``Chemistry for Chemical Genomics.``
    in „Chemical Genomics: Reviews and Protocols“, E.D. Zanders (ed.), Humana Press, Totowa, New Jersey, 2005
  • ``Solution phase parallel synthesis and evaluation of MAPK inhibitory activities of close structural analogues of a Ras pathway modulator.``

    Bioorg. Med. Chem. Lett. 2004, 14, 3957-3962